Casandra
Casandra Test Code MC18584Version 1 (DRAFT)
Performing Lab
Coccidioides Antibody Reflex, Complement Fixation and Immunodiffusion, Serum
Clinical Use
Order TestUse
Serologic testing for coccidioidomycosis. Detection of IgG antibody by complement fixation and precipitating IgM/IgG antibodies by immunodiffusion in serum, useful in patients with pulmonary or meningeal infection and history of travel or exposure to endemic areas. Over 90% of primary symptomatic cases detected by combined ID and CF testing.
Special Instructions
Not provided.
Limitations
Antibodies (IgM and IgG) may persist after infection has resolved; CF titers may persist for months, making active infection interpretation complex.
Test Details
New York Approved
Methodology
Immunoassay
Biomarkers
IgG antibody (CF)
ProteinComplement Fixation titer
Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)
IgG antibody (ID)
ProteinImmunodiffusion IgG
Other • Categorical (e.g., Positive / Negative / Indeterminate)
IgM antibody (ID)
ProteinImmunodiffusion IgM
Other • Categorical (e.g., Positive / Negative / Indeterminate)
LOINC Codes
Order Codes
- 26625-4 - Coccidioides Ab Ser Ql
Result Codes
- 33379-9 - Coccidioides Ab Ser Ql CF
- 46182-2 - Coccidioides IgG Ser Ql
- 46183-0 - Coccidioides IgM Ser Ql
Result Turnaround Time
4-7 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Serum
Volume
Not provided
Minimum Volume
1.2 mL
Storage Instructions
Refrigerated (preferred) 14 days; Frozen 14 days
Causes for Rejection
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 14 days |