Coenzyme Q10, Total, Plasma
Use
This test is used for the diagnosis of primary coenzyme Q10 (CoQ10) deficiencies in patients not supplemented with CoQ10. It is also employed in monitoring patients receiving statin therapy or those undergoing treatment for various degenerative conditions like Parkinson and Alzheimer diseases. Accurate quantitation of total CoQ10 is particularly important when specimens are hemolyzed. However, the test is not useful for distinguishing between primary and acquired CoQ10 deficiencies.
Special Instructions
Not provided.
Limitations
This test does not distinguish between primary and acquired CoQ10 deficiencies. It also does not quantitate reduced CoQ10. The most reliable test for diagnosing primary ubiquinone biosynthesis defects is direct CoQ10 measurement in muscle tissue.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 27923-2 - Ubiquinone10 SerPl-mCnc
- 27923-2 - Ubiquinone10 SerPl-mCnc
- 59462-2 - Clinical biochemist review
- 18771-6 - Provider signing name
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Plastic vial
Collection Instructions
Immediately after collection, place specimen on wet ice. Maintain on wet ice until processing. Within 3 hours of collection, centrifuge, aliquot plasma into a plastic vial, and freeze immediately.
Patient Preparation
Fasting: 8 hours, required
Causes for Rejection
Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 7 days |
| Frozen | 60 days |