Use

Useful for diagnosing Wilson disease and primary biliary cirrhosis using liver tissue specimens. Elevated hepatic copper (>250 mcg/g dry weight) strongly suggests Wilson disease; moderately elevated levels (50–250 mcg/g dry weight) may indicate cholestatic liver disease or heterozygous carrier status. Interpretation should consider histology and other biochemical tests, and contamination must be ruled out. A minimum dry tissue weight of 0.3 mg is required, and fresh‑frozen unfixed tissue is strongly recommended to avoid contamination from copper‑containing fixatives. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/Overview/8687?utm_source=openai))