Corticosterone, Serum
Use
The test is used for diagnosing suspected 11-hydroxylase deficiency, including differentiating 11-beta-hydroxylase 1 (CYP11B1) vs 11-beta-hydroxylase 2 (CYP11B2) deficiency, and diagnosing glucocorticoid-responsive hyperaldosteronism. It is also useful for evaluating infants with positive newborn screening results for congenital adrenal hyperplasia when 17-hydroxyprogesterone elevations are moderate, suggesting possible 11-hydroxylase deficiency.
Special Instructions
The preferred sample collection time is at 8 a.m. for optimal results. Serum must be centrifuged and aliquoted into a plastic vial immediately.
Limitations
Interpretation requires experience, particularly for less common CAH variants. Mineralocorticoid results within 7 days of newborns should be interpreted with caution as levels can be significantly elevated in this period.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 2139-4
- 2139-4
Result Turnaround Time
3-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Plastic vial
Collection Instructions
Morning (8 a.m.) specimen is preferred. Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 28 days |
| Frozen | 28 days |