Cryptococcus Antigen Titer, Lateral Flow Assay, Spinal Fluid
Use
This test is useful for monitoring Cryptococcus antigen titers in cerebrospinal fluid and aiding in the diagnosis of cryptococcosis. Cryptococcosis is an invasive fungal infection caused by Cryptococcus neoformans or Cryptococcus gattii. The presence of cryptococcal antigen in any body fluid is indicative of cryptococcosis. Disseminated infection is usually accompanied by a positive serum test, and declining titers may indicate regression of infection. However, this test should not be used as a test of cure or to guide treatment decisions.
Special Instructions
Not provided.
Limitations
A traumatic lumbar puncture and contamination of the cerebrospinal fluid (CSF) specimen with serum may lead to a false positive result. Cryptococcus antigen titers acquired by different assay methods are not interchangeable, and titers should be monitored using the same method on serially collected samples. A negative result does not preclude diagnosis of cryptococcosis, particularly if only a single specimen has been tested and the patient shows symptoms consistent with cryptococcosis. Testing should not be performed as a screening procedure for the general population and should only be performed when clinical evidence suggests the diagnosis of cryptococcal disease.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Lateral Flow)
Biomarkers
Cryptococcus gattii
MicroorganismCryptococcus neoformans
Microorganism
LOINC Codes
- 9817-8 - Cryptoc Ag Titr CSF IA
- 9817-8 - Cryptoc Ag Titr CSF IA
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Sterile vial
Collection Instructions
Submit specimen from collection vial 2 (preferred), 3, or 4.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 14 days |