D-Lactate, Urine
Use
Preferred test for diagnosing D‑lactate acidosis, especially in patients with jejunoileal bypass and short‑bowel syndrome. D‑lactate is produced by bacterial fermentation when carbohydrates are malabsorbed, leading to metabolic acidosis and neurologic symptoms. Routine blood lactate assays detect only L‑lactate, making specific D‑lactate testing necessary. Urine is the preferred specimen due to ready excretion of D‑lactate. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/Overview/8873?utm_source=openai))
Special Instructions
Patient must complete the Biochemical Genetics Patient Information form. Collect a timed or random urine specimen in a plastic urine tube (10 mL; T068), with 0.50 mL volume. No preservative is used. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/Overview/8873?utm_source=openai))
Limitations
This test measures only D‑lactate and should not be confused with L‑lactate, which accumulates in other forms of metabolic acidosis. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/Overview/8873?utm_source=openai))
New York Approved
Methodology
Mass Spectrometry (GC-MS (interpreted as LC‑MS/MS equivalent))
Biomarkers
LOINC Codes
- 14046-7
- 14046-7
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
0.50 mL
Minimum Volume
0.15 mL
Container
Plastic urine tube (10 mL; T068)
Collection Instructions
Collect a timed or random urine specimen; no preservative.
Causes for Rejection
Urine collected with preservative or unsuited specimen; all specimens evaluated for test suitability.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 90 days |
| Refrigerated | 90 days |
| Frozen | 90 days |