Dendritic Cell and Monocyte Enumeration, Blood
Use
This test helps in diagnosing patients suspected of having defects in innate immunity, especially those involving the development of monocytes and dendritic cells. It is suited for identifying issues that may present alone or as part of a broader clinical syndrome. The test includes an enumeration of plasmacytoid dendritic cells, myeloid dendritic cells, and classical monocytes, contributing to the understanding of immunological conditions like genetic deficiencies affecting dendritic cell function.
Special Instructions
Not provided.
Limitations
This test has not been validated for diagnosing hematologic malignancies, and the full range of immune defects caused by dendritic cell deficiency is not yet established. A decrease in dendritic cell or monocyte counts may not necessarily be present in all individuals with a specific deficiency due to variable expressivity and lack of established genotype-phenotype correlations in certain conditions.
New York Approved
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
Classical Monocytes
Cell TypeMyeloid Dendritic Cells
Cell TypePlasmacytoid Dendritic Cells
Cell Type
LOINC Codes
- 104547-5 - Monocyte and dendritic cell pnl Bld FC
- 104548-3 - Monocytes # Bld FC
- 104549-1 - pDC # Bld FC
- 104550-9 - mDC # Bld FC
- 48767-8 - Annotation comment Imp
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3 mL
Minimum Volume
1 mL
Container
Green top (sodium heparin)
Collection Instructions
Send the whole blood specimen in the original tube. Do not open or aliquot.
Causes for Rejection
Gross hemolysis or clotted samples
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 36 hours |