Dengue Virus Antibody/Antigen Panel, Serum
Use
This test aids in diagnosing dengue virus infection by detecting IgM and IgG antibodies as well as the nonstructural protein 1 (NS1) antigen. The presence of NS1 antigen overlaps with the dengue virus viremic phase and can be used as an acute phase marker for infection. The detection of NS1 antigen and/or anti-dengue virus IgM is suggestive of recent exposure or acute infection with the dengue virus.
Special Instructions
Test results should be considered along with clinical evaluation, including exposure history and clinical presentation. False-positive results can occur in individuals infected with other flaviviruses such as Zika virus, West Nile virus, and St. Louis encephalitis virus. Obtain a detailed exposure history and conduct additional laboratory testing if necessary.
Limitations
False-positive results may occur in individuals with flavivirus infections such as West Nile and Zika virus. Positive results may not be valid in those who have received blood transfusions recently. Negative results may occur if the specimen is collected more than 7 days after symptom onset. Immunosuppressed patients might not show accurate results.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 104595-4
- 29661-6
- 29663-2
- 75377-2
- 69048-7
Result Turnaround Time
1-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.8 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into plastic vial.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus, or heat-inactivated specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 14 days |