Disseminated Intravascular Coagulation/Intravascular Coagulation and Fibrinolysis (DIC/ICF) Profile, Plasma
Use
The Disseminated Intravascular Coagulation (DIC)/Intravascular Coagulation and Fibrinolysis (ICF) Profile is crucial for establishing laboratory evidence of DIC, a complex disorder characterized by both bleeding and thrombosis. It is often a secondary condition associated with a variety of underlying issues such as sepsis, trauma, malignancies, and immunological disorders. By measuring various coagulation parameters, this test provides insight into the balance or imbalance of coagulation and fibrinolysis, facilitating the detection of DIC and aiding in the management of the underlying condition.
Special Instructions
Patient preparation is vital. Patients should not be on Coumadin or heparin therapy during sampling, as these can affect the results, which must be noted on the request form. Follow the Coagulation Guidelines for Specimen Handling and Processing for optimum results. Ensure specimens are double-centrifuged and platelet-poor plasma is used to avoid erroneous results.
Limitations
This test profile does not detect all bleeding disorders, such as von Willebrand disease. In patients with amyloidosis and bleeding symptoms, a limited bleeding diathesis profile is suggested instead. Moreover, external factors like improper handling can affect the results. Platelet contamination, hemolysis, and lipemia are potential pre-analytical issues that may lead to rejection or inaccurate results. Patients already on certain anticoagulant therapies may show altered results; exact interpretation requires clinical correlation.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 98125-8
- 14979-9
- 48664-7
- 46717-5
- 69049-5
- 6301-6
- 5902-2
Result Turnaround Time
1-7 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
5 mL
Minimum Volume
Not provided
Container
Light-blue top (3.2% sodium citrate)
Collection Instructions
Centrifuge, transfer all plasma into a plastic vial, and centrifuge plasma again. Aliquot plasma (1 mL per aliquot) into 5 separate plastic vials, leaving 0.25 mL in the bottom of centrifuged vial.
Patient Preparation
Patient should not be receiving Coumadin or heparin. If so, note on request.
Storage Instructions
Freeze plasma immediately at -20 degrees C or lower, ideally -40 degrees C.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 14 days |