Encainide (Enkaid), ODE and MODE
Use
This test measures the levels of encainide and its active metabolites, O-Demethylencainide (ODE) and 3-Methoxy-ODE (MODE) in plasma or serum. Encainide is a class Ic antiarrhythmic agent used to manage certain types of cardiac arrhythmias. Monitoring the drug and metabolite levels can help assess therapeutic ranges and identify patients who do not metabolize the drug to its active forms, facilitating dosage adjustments and improving patient management.
Special Instructions
Specimens should be sent refrigerated to ensure stability. A green-top (sodium heparin) tube should be used for plasma, and a plain red-top tube should be used for serum. Plasma or serum gel tubes are not acceptable.
Limitations
Test results may be influenced by improper specimen handling, such as using unacceptable tube types or incorrect storage temperatures. Hemolysis, lipemia, and icterus are not causes for rejection but may affect the accuracy of test results. Individual variations in metabolism may also affect the levels of active metabolites, and 10% of patients do not form therapeutic concentrations of ODE and MODE.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 3589-9
- 10997-5
- 10973-6
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.25 mL
Container
Plastic vial
Collection Instructions
Draw blood in a green-top (sodium heparin) tube. Spin down and send sodium heparin plasma refrigerated.
Storage Instructions
Refrigerated for 14 days preferred, ambient for 72 hours, frozen for 180 days.
Causes for Rejection
NA
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 14 days |
| Frozen | 180 days |