Exostosin 2 (EXT2) Immunostain, Technical Component Only
Use
Identification of exostosin 2 associated membranous nephropathy. Exostosin 1 (EXT1) and exostosin 2 (EXT2) are associated with a subset of primary membranous nephropathy where phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) are not the target antigens. This test may help identify patients with secondary, autoimmune membranous nephropathy.
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation, only technical performance of the stain. Interpretation of this test should be performed by a qualified pathologist in the context of the patient's clinical history and other diagnostic tests. The age of the paraffin sections can affect immunoreactivity, and best practices dictate that paraffin sections be cut within 6 weeks. Environmental factors may alter the charge of glass slides, affecting staining. Protect slides from high humidity and heat to maintain stability.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Exostosin 1
ProteinExostosin 2
Protein
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Storage Instructions
Attach green 'Attention Pathology' and pink 'Immunostain Technical Only' labels to the container. Store slides appropriately before transport.
Causes for Rejection
Reject if tissue is wet, frozen, cytology smears, nonformalin fixed, nonparaffin embedded, noncharged slides, ProbeOn slides, Snowcoat slides.