Factor VIII Inhibitor Profile, Technical Interpretation
Use
This test provides a technical interpretation of inhibitor to factor VIII testing. It is particularly useful for patients with congenital FVIII deficiency (hemophilia A) who develop antibodies in response to therapeutic infusions of factor VIII concentrate. It can also be used for older nonhemophiliac adult patients, postpartum women, and patients with other autoimmune illnesses who may develop factor VIII inhibitors. An interpretive comment will be provided based on factor activity results to determine the presence or absence of a factor VIII inhibitor.
Special Instructions
Not provided.
Limitations
This test is not useful for detecting lupus-like circulating anticoagulant inhibitors, nonspecific circulating anticoagulants, or other inhibitors not specific for coagulation factors. A potent lupus-like anticoagulant may occasionally cause false-positive results for specific factor inhibitors such as factor VIII or IX.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 69049-5 - Coagulation specialist review
- 69049-5 - Coagulation specialist review
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
Not provided
Minimum Volume
Not provided
Container
Na Cit
Collection Instructions
The specimen must be collected as part of the Factor VIII Inhibitor Evaluation, Plasma profile.
Causes for Rejection
Gross hemolysis, gross lipemia, and gross icterus are causes for rejection.
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 14 days |