Factor XI Inhibitor Evaluation, Plasma
Use
Detection and quantitation of inhibitor to coagulation factor XI. It helps in diagnosing conditions in patients with congenital factor XI deficiency (hemophilia C) or after infusion of plasma or factor XI concentrates. It is not useful for detecting lupus-like anticoagulant inhibitors or non-specific circulating anticoagulants.
Special Instructions
Not provided.
Limitations
The test is limited by its inability to detect lupus-like anticoagulant inhibitors or non-specific circulating anticoagulants. Potent lupus-like anticoagulant may cause false-positive results for specific factor inhibitors such as factor VIII or IX.
New York Approved
Methodology
Other
Biomarkers
Coagulation Factor XI
Analyte
LOINC Codes
- 96453-6 - Fact XI Act + Inhib Pnl PPP
- 3226-8 - Fact XI Act/Nor PPP
- 69049-5 - Coagulation specialist review
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
3 mL in 3 plastic vials, each containing 1 mL
Minimum Volume
2 Plastic vials, each containing 1 mL
Container
Light-blue top (3.2% sodium citrate) for collection, Polypropylene plastic vials for submission
Collection Instructions
Specimen must be collected prior to factor replacement therapy. Centrifuge, transfer all plasma into a plastic vial, centrifuge again. Aliquot plasma (1-2 mL per aliquot) into 3 separate plastic vials. Freeze plasma immediately at -20°C, ideally at -40°C or below.
Patient Preparation
Fasting for 8 hours preferred; do not take Coumadin, heparin, direct thrombin inhibitors, or direct factor Xa inhibitors.
Storage Instructions
Freeze plasma immediately at -20°C or ideally at -40°C or below.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 14 days |