Fibrinogen, Plasma
Use
The Fibrinogen, Plasma test is used for detecting increased or decreased fibrinogen concentration, which may be of acquired or congenital origin. It is also useful in monitoring the severity and treatment of disseminated intravascular coagulation and fibrinolysis. Fibrinogen, also known as factor I, is a plasma protein synthesized in the liver and transformed by thrombin into a fibrin gel, crucial for clot formation. It acts as an acute phase reactant, and changes in its levels can be indicative of inflammatory illnesses, liver disease, and other conditions.
Special Instructions
Specimen must be double-centrifuged and frozen immediately to avoid platelet contamination, which could cause spurious results. Detailed handling and processing instructions should be followed as per the Coagulation Guidelines for Specimen Handling and Processing.
Limitations
Inaccurate test results can occur if specimens are not handled properly. Patients with dysfibrinogenemias may have low fibrinogen concentrations that could mislead unless antigen concentration is measured. Direct oral anticoagulants and high heparin concentrations can falsely decrease fibrinogen levels. Sample rejection criteria include gross hemolysis, which can impact test results.
FDA ApprovedNew York Approved
Methodology
Other (Turbidimetric)
Biomarkers
LOINC Codes
- 3255-7
- 3255-7
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
Light-blue top (3.2% sodium citrate); Submission Container: Plastic vial
Collection Instructions
Centrifuge, transfer all plasma into a plastic vial, and centrifuge again. Aliquot plasma into a plastic vial leaving 0.25 mL in the vial. Freeze immediately at -20°C or below.
Storage Instructions
Freeze plasma immediately; extend stability is 14 days if frozen; 24 hours if kept ambient.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Frozen | 14 days |