Fluoride, Plasma
Use
This test is useful for assessing accidental fluoride ingestion and monitoring patients receiving sodium fluoride for bone disease as well as those undergoing voriconazole therapy. High plasma fluoride concentrations can lead to adverse skeletal effects, such as osteomalacia and periostitis, indicating excessive fluoride exposure. Fluoride is utilized in dental preparations and as an antiosteoporotic agent but prolonged high exposure produces changes in bone morphology.
Special Instructions
Centrifuge and aliquot plasma into a plastic vial. Glass tubes are not acceptable. The specimen stability is 14 days refrigerated, ambient, or frozen.
Limitations
This test method uses ion-selective electrode technology, which can be influenced by solution pH. Solutions below pH 5 may yield falsely low readings as hydrogen ions complex with fluoride ions. Conversely, solutions above pH 9 may result in falsely elevated readings due to hydroxyl ion interference with the electrode.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 14726-4
- 14726-4
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
3 mL
Minimum Volume
1.2 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot plasma into a plastic vial. Glass tubes are not acceptable.
Storage Instructions
Refrigerated (preferred) 14 days, ambient 14 days, frozen 14 days.
Causes for Rejection
Glass tubes are not acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |