FosB, Immunostain, Technical Component Only
Use
FosB is a member of the Fos transcription factor family and a component of the activator protein-1 (AP-1) protein complex. It is useful in diagnosing pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma and can help distinguish it from histologic mimics. FosB is also found in a subset of epithelioid hemangiomas, making it a potential diagnostic marker for these conditions.
Special Instructions
This test includes only the technical performance of the stain and not a pathologist interpretation. Immunohistochemistry (IHC)/in situ hybridization (ISH) stains should not be ordered with PATHC / Pathology Consultation, as the technical component stains will be canceled.
Limitations
The age of a cut paraffin section can affect immunoreactivity, and stability thresholds vary widely and are antigen-dependent. The charge of glass slides can be influenced by environmental factors, potentially affecting slide staining. Best practices recommend cutting paraffin sections within 6 weeks and minimizing the storage and exposure time of positively charged slides to humidity and heat.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Storage Instructions
Best practices for storage of positively charged slides: Minimize time stored after unpackaging, limit exposure to high humidity and heat, and minimize exposure to plastics.
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |
| Refrigerated | Refrigerated if needed |