Gastrointestinal Dysmotility, Autoimmune/Paraneoplastic Evaluation, Serum
Use
This test is useful for investigating unexplained weight loss, early satiety, anorexia, nausea, vomiting, constipation, or diarrhea in patients with a past or family history of cancer or autoimmunity. It helps in directing a focused search for cancer and is also used to investigate gastrointestinal symptoms appearing post-cancer therapy, aiding in differentiating autoimmune gastrointestinal dysmotility from chemotherapy effects. Moreover, it detects early evidence of cancer recurrence in patients with a rising titer of autoantibodies.
Special Instructions
This test should not be requested in patients who have recently received radioisotopes, as they may cause potential assay interference. Specimens will be screened for radioactivity before analysis and held for a week if radioactive. Collection is recommended before starting immunosuppressant medication or intravenous immunoglobulin (IVIg) treatment.
Limitations
Negative results do not exclude autoimmune gastrointestinal dysmotility or cancer. Results may be affected if the specimen is collected post-treatment with intravenous immunoglobulin (IVIg), likely causing false positives.
New York Approved
Methodology
Immunoassay (Indirect Immunofluorescence Assay (IFA))
Biomarkers
LOINC Codes
- 97557-3
- 33615-6
- 72504-4
- 94694-7
- 84925-7
- 69048-7
- 48767-8
- 94287-0
- 94285-4
- 94676-4
- 101907-4
Result Turnaround Time
8-12 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
4 mL
Minimum Volume
2 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Patient Preparation
For optimal antibody detection, specimen collection is recommended before starting immunosuppressant medication or IVIg treatment.
Causes for Rejection
Gross hemolysis, Gross lipemia, Gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |