Hemoglobin Stability, Blood
Use
The test is useful for the work-up of congenital hemolytic anemias and detecting unstable hemoglobin variants which may cause hemolytic anemia, varying in severity based on the variant. They are inherited as autosomal dominant traits and can produce a range of clinical symptoms from mild to severe anemia. Features may include anisocytosis, poikilocytosis, basophilic stippling, polychromasia, hypochromia on peripheral smear, increased reticulocyte count, splenomegaly, and presence of Heinz bodies.
Special Instructions
This test cannot be ordered independently but only as part of a profile or as a reflex. It is associated with other evaluations like Hemolytic Anemia Evaluation, Hemoglobin Electrophoresis Evaluation, Thalassemia and Hemoglobinopathy Evaluation, Erythrocytosis Evaluation, and Methemoglobinemia Evaluation.
Limitations
False-positive results can occur in specimens containing more than 5% fetal hemoglobin or in specimens older than a week. The test has limitations in terms of detecting hemoglobinopathies solely, hence confirmatory tests such as hemoglobin electrophoresis are recommended to identify the specific hemoglobin variant.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 4639-1
- 4639-1
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
Not provided
Minimum Volume
1 mL
Container
EDTA tube
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |