Use

The test is useful for the work-up of congenital hemolytic anemias and detecting unstable hemoglobin variants which may cause hemolytic anemia, varying in severity based on the variant. They are inherited as autosomal dominant traits and can produce a range of clinical symptoms from mild to severe anemia. Features may include anisocytosis, poikilocytosis, basophilic stippling, polychromasia, hypochromia on peripheral smear, increased reticulocyte count, splenomegaly, and presence of Heinz bodies.