Use

This test is used for prenatal testing for hemophilia A when an F8 intron 22 inversion has been identified in a family member. The intron 22 inversion accounts for approximately 45 percent of variants associated with severe hemophilia A. A known family inversion is required for analysis. Knowledge of familial inversion enables targeted prenatal diagnosis. If the familial inversion is not detected in an affected male or obligate female carrier, further methods such as F8 sequencing may be considered.