Hepatitis B Virus e Antigen, Serum
Use
This test is useful for determining the presence or absence of detectable hepatitis B virus e antigen in individuals with chronic hepatitis B infection. It helps in monitoring infection status and determining the infectivity of hepatitis B virus (HBV) carriers. Additionally, it is useful in monitoring the serologic response of chronically HBV-infected patients receiving antiviral therapy.
Special Instructions
Date of collection is required for processing the sample. For 24 hours before specimen collection, the patient should not take multivitamins or dietary supplements containing biotin (vitamin B7). If ordered with HBVQN, send separate vials.
Limitations
This assay has not been licensed by the US Food and Drug Administration for testing cord blood specimens or screening donors of blood, plasma, human cell, or tissue products. For diagnostic purposes, results should always be assessed in conjunction with the patient’s medical history, clinical examination, and other findings. Specimens should not be taken from patients receiving therapy with high biotin doses until at least 8 hours following the last biotin administration. False positive results due to non-specific reactivity cannot be ruled out, and negative results may occur during early infection due to delayed seroconversion or low antigen levels.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 13954-3
- 13954-3
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.7 mL
Minimum Volume
0.6 mL
Container
Plastic vial
Collection Instructions
Centrifuge blood collection tube per manufacturer's instructions. Aliquot serum into plastic vial.
Patient Preparation
For 24 hours before specimen collection, patient should not take multivitamins or dietary supplements containing biotin (vitamin B7).
Storage Instructions
Frozen (preferred) for 90 days, Ambient for 72 hours, Refrigerated for 6 days.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus, heat-inactivated specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 6 days |
| Frozen | 90 days |