Hereditary Common Cancer Panel, Varies
Use
Evaluating hereditary cancer for patients with a personal or family history suggestive of a hereditary cancer syndrome using a panel of 36 genes. Establishing a diagnosis of a hereditary cancer syndrome allowing for targeted cancer surveillance based on associated risks. Identifying genetic variants associated with increased risk for cancer, allowing for predictive testing, and appropriate screening of at-risk family members. Therapeutic eligibility with poly adenosine diphosphate-ribose polymerase (PARP) inhibitors based on certain gene alterations (eg, BRCA1, BRCA2) in selected tumor types.
Special Instructions
Customization of this panel and single gene analysis for any gene present on this panel are available. Targeted testing for familial variants is available for the genes on this panel. Patients should consult the laboratory for instructions if a bone marrow transplant has occurred, as it may interfere with testing. Informed consent is required for New York clients.
Limitations
Next-generation sequencing may not detect all types of genomic variants. False-negative or false-positive results may occur. The depth of coverage may vary for some target regions; assay performance below the minimum acceptable criteria or for failed regions will be noted. Negative results do not rule out a genetic disorder. Certain regions of genes may not be well-evaluated due to homology, GC content, or repetitive sequences. Confirmation of some variants may be required using alternate methods. Deletions-insertions greater than 40 bp may be less reliably detected.
New York Approved
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 97656-3
- 62364-5
- 31208-2
- 50397-9
- 82939-0
- 69047-9
- 99622-3
- 48767-8
- 85069-3
- 48018-6
- 18771-6
Result Turnaround Time
21-28 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3 mL
Minimum Volume
1 mL
Container
Lavender top (EDTA) or yellow top (ACD)
Collection Instructions
Invert several times to mix blood. Send whole blood specimen in original tube. Do not aliquot.
Patient Preparation
A previous bone marrow transplant from an allogenic donor will interfere with testing.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 4 days |
| Frozen | 4 days |