Hereditary Common Cancer Panel, Varies

Casandra

Casandra Test Code MC56991Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID COMCPCPT Codes 81201, 81408, 81162, 81406, 81404, 81403, 81405, 81292, 81295, 81298, 81307, 81317, 81321, 81351, 81479

Hereditary Common Cancer Panel, Varies

Clinical Use

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Use

Evaluating hereditary cancer for patients with a personal or family history suggestive of a hereditary cancer syndrome using a panel of 36 genes. Establishing a diagnosis of a hereditary cancer syndrome allowing for targeted cancer surveillance based on associated risks. Identifying genetic variants associated with increased risk for cancer, allowing for predictive testing, and appropriate screening of at-risk family members. Therapeutic eligibility with poly adenosine diphosphate-ribose polymerase (PARP) inhibitors based on certain gene alterations (eg, BRCA1, BRCA2) in selected tumor types.

Special Instructions

Not provided.

Limitations

Next-generation sequencing may not detect all types of genomic variants. False-negative or false-positive results may occur. The depth of coverage may vary for some target regions; assay performance below the minimum acceptable criteria or for failed regions will be noted. Negative results do not rule out a genetic disorder. Certain regions of genes may not be well-evaluated due to homology, GC content, or repetitive sequences. Confirmation of some variants may be required using alternate methods. Deletions-insertions greater than 40 bp may be less reliably detected.

Test Details

New York Approved

Methodology

NGS (Targeted)

Biomarkers

Mutation (36 genes)

APCATMAXIN2BARD1BMPR1ABRCA1BRCA2BRIP1CDH1CDK4CDKN2ACHEK2DICER1EPCAMGREM1HOXB13MEN1MLH1MSH2MSH3MSH6MUTYHNBNNF1NTHL1PALB2PMS2POLD1POLEPTENRAD51CRAD51DRETSMAD4STK11TP53