Hereditary Common Cancer Panel, Varies
Use
Evaluating hereditary cancer for patients with a personal or family history suggestive of a hereditary cancer syndrome using a panel of 36 genes. Establishing a diagnosis of a hereditary cancer syndrome allowing for targeted cancer surveillance based on associated risks. Identifying genetic variants associated with increased risk for cancer, allowing for predictive testing, and appropriate screening of at-risk family members. Therapeutic eligibility with poly adenosine diphosphate-ribose polymerase (PARP) inhibitors based on certain gene alterations (eg, BRCA1, BRCA2) in selected tumor types.
Special Instructions
Not provided.
Limitations
Next-generation sequencing may not detect all types of genomic variants. False-negative or false-positive results may occur. The depth of coverage may vary for some target regions; assay performance below the minimum acceptable criteria or for failed regions will be noted. Negative results do not rule out a genetic disorder. Certain regions of genes may not be well-evaluated due to homology, GC content, or repetitive sequences. Confirmation of some variants may be required using alternate methods. Deletions-insertions greater than 40 bp may be less reliably detected.
New York Approved
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 97656-3 - Hereditary Cancer Multigene Anl Bld/T
- 62364-5 - Test performance info Spec
- 31208-2 - Specimen source
- 50397-9 - Mol dx interp Bld/T Ql
- 82939-0 - Genetic variant details Bld/T
- 69047-9 - Geneticist review
- 99622-3 - Patient resource info
- 48767-8 - Annotation comment Imp
- 85069-3 - Lab test method
- 48018-6 - Gene studied ID
- 18771-6 - Provider signing name
Result Turnaround Time
21-28 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3 mL
Minimum Volume
1 mL
Container
Lavender top (EDTA) or yellow top (ACD)
Collection Instructions
Invert several times to mix blood. Send whole blood specimen in original tube. Do not aliquot.
Patient Preparation
A previous bone marrow transplant from an allogenic donor will interfere with testing.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 4 days |
| Frozen | 4 days |