Hereditary Gastrointestinal Cancer Panel, Varies

Clinical Use

Use

This test is useful for evaluating patients with a personal or family history suggestive of a hereditary gastrointestinal cancer or hereditary polyposis syndrome. It helps in establishing a diagnosis of hereditary gastrointestinal cancer syndrome or hereditary polyposis syndrome, allowing for targeted cancer surveillance based on associated risks. Additionally, it identifies genetic variants associated with increased risk for gastrointestinal cancer and polyposis, enabling predictive testing and appropriate screening of at-risk family members.

Special Instructions

Not provided.

Limitations

Next-generation sequencing may not detect all types of genomic variants. False-negative or false-positive results may occur. Depth of coverage may be variable for some target regions, and performance below the minimum acceptable criteria or for failed regions will be noted. Negative results do not rule out the diagnosis of a genetic disorder. There may be regions of genes that cannot be effectively evaluated by sequencing or deletion and duplication analysis due to technical limitations, high GC content, and repetitive sequences. The test is not designed to detect low levels of mosaicism or differentiate between somatic and germline variants.

Test Details

New York Approved