Hereditary Prostate Cancer Panel
Use
This test is used for evaluating patients with a personal or family history suggestive of a hereditary prostate cancer syndrome. It aids in establishing a diagnosis of a hereditary prostate cancer syndrome, allowing for targeted cancer surveillance based on associated risks. It also identifies genetic variants associated with an increased risk for prostate cancer, enabling predictive testing and appropriate screening of at-risk family members. The test is essential for determining therapeutic eligibility for poly adenosine diphosphate-ribose polymerase (PARP) inhibitors based on certain gene alterations, such as BRCA1 and BRCA2.
Special Instructions
Not provided.
Limitations
Next-generation sequencing may not detect all types of genomic variants. In rare cases, false-negative or false-positive results can occur. Certain gene regions may not be effectively evaluated due to technical limitations such as homology, high guanine-cytosine (GC) content, and repetitive sequences. The test is not designed to detect low levels of mosaicism or to differentiate between somatic and germline variants. Additionally, results may be inaccurate in patients with an allogeneic hematopoietic stem cell transplant or a recent blood transfusion.
New York Approved
Methodology
NGS
Biomarkers
LOINC Codes
- 100213-8 - Prostate cancer multigene analysis Bld/T
- 62364-5 - Test performance info Spec
- 31208-2 - Specimen source
- 50397-9 - Mol dx interp Bld/T Ql
- 82939-0 - Genetic variant details Bld/T
- 69047-9 - Geneticist review
- 99622-3 - Patient resource info
- 48767-8 - Annotation comment Imp
- 85069-3 - Lab test method
- 48018-6 - Gene studied ID
- 18771-6 - Provider signing name
Result Turnaround Time
14-21 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3 mL
Minimum Volume
1 mL
Container
Lavender top (EDTA) or yellow top (ACD)
Collection Instructions
Invert several times to mix blood. Send whole blood specimen in original tube. Do not aliquot.
Patient Preparation
A previous bone marrow transplant from an allogenic donor will interfere with testing.
Storage Instructions
Ambient 4 days/Refrigerated 4 days/Frozen 4 days
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 4 days |
| Frozen | 4 days |