Hereditary Renal Cancer Panel, Varies
Use
This test is valuable for evaluating patients who have a personal or family history indicative of a hereditary renal cancer syndrome. It aids in establishing a diagnosis of such syndromes, facilitating targeted cancer surveillance based on associated risks. The test helps identify genetic variants linked to increased risks for renal and other cancers, allowing for predictive testing and screening of at-risk family members.
Special Instructions
Testing minors for adult-onset predisposition syndromes is discouraged by professional organizations. Customization options are available for single gene analysis on this panel. Consider calling the laboratory for more information regarding familial variant testing options.
Limitations
Next-generation sequencing may not detect all genomic variants. False-negative or false-positive results can occur, and coverage may be variable for some regions. Negative results do not rule out genetic disorders. Specific regions with high GC content or repetitive sequences may not be effectively evaluated. Detection of deletions/duplications beyond included genes may not be complete. Additional methodologies might confirm select variants.
New York Approved
Methodology
NGS
Biomarkers
LOINC Codes
- 106781-8
- 62364-5
- 31208-2
- 50397-9
- 82939-0
- 69047-9
- 99622-3
- 48767-8
- 85069-3
- 48018-6
- 18771-6
Result Turnaround Time
14-21 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3 mL
Minimum Volume
1 mL
Container
Lavender top (EDTA) or yellow top (ACD)
Collection Instructions
Invert several times to mix blood. Send whole blood specimen in original tube. Do not aliquot.
Patient Preparation
A previous bone marrow transplant from an allogenic donor will interfere with testing.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 4 days |
| Frozen | 4 days |