Herpes Simplex Virus (HSV), Molecular Detection, PCR, Varies

Casandra

Casandra Test Code MC32022Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID HSVPVCPT Code 87529

Herpes Simplex Virus (HSV), Molecular Detection, PCR, Varies

Clinical Use

Use

This test aids in the rapid diagnosis of herpes simplex virus (HSV) infections by detecting HSV DNA qualitatively in nonblood clinical specimens. HSV types 1 and 2, belonging to the Herpesviridae family, can cause a range of infections from mild stomatitis to severe disseminated disease. Clinical conditions associated with HSV include gingivostomatitis, keratitis, encephalitis, vesicular skin eruptions, aseptic meningitis, neonatal herpes, genital tract infections, and disseminated primary infection. The test results can rapidly support diagnosis when clinical findings suggest HSV infection.

Special Instructions

Specimen source must be indicated along with the anatomical site of collection. For blood specimens, use HSVPB; for cerebrospinal fluid (CSF), use HSVC. If varicella-zoster virus is suspected, order VZVPV. Testing should not be used for screening asymptomatic patients. Specimen stability information indicates 7 days when refrigerated or frozen.

Limitations

The test may detect viral nucleic acid shedding in asymptomatic individuals, particularly from dermal or genital sites. Negative results do not eliminate the possibility of HSV infection. As this assay may provide an indeterminate result between HSV-1 and HSV-2, further typing with a new specimen may be necessary to differentiate. Proper patient history is necessary to interpret results accurately.

Test Details

New York Approved