Herpesvirus 7 (HHV-7) DNA, Quantitative Real-Time PCR

Casandra

Casandra Test Code MC66270Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID FHV7PCPT Code 87799

Herpesvirus 7 (HHV-7) DNA, Quantitative Real-Time PCR

Clinical Use

Use

The Herpesvirus 7 (HHV-7) DNA, Quantitative Real-Time PCR test is employed in detecting and quantitatively measuring the presence of HHV-7 DNA in clinical specimens. HHV-7 is a member of the Herpesviridae family, and it is associated with febrile seizures and roseola infantum in children. In adults, it is less commonly symptomatic, but can potentially lead to complications in immunocompromised patients, such as those undergoing organ transplantation or suffering from HIV. This test aids clinicians in the diagnosis, management, and monitoring of herpesvirus infections, particularly in immunocompromised individuals or when clinical symptoms suggest HHV-7 involvement.

Special Instructions

The test requires careful coordination in specimen collection and handling to maintain specimen integrity, especially ensuring specimens are kept refrigerated and not frozen. For optimal results, a source label is required for processing the specimen. The minimum specimen volume must be adhered to avoid sample depletion and the need for additional collection.

Limitations

The HHV-7 PCR test is specific to HHV-7 DNA and does not detect other members of the Herpesviridae family. False-negative results may occur if the viral DNA load in the specimen is below the detection limit of the assay or if the specimen is improperly collected, transported, or stored. Additionally, mutations or polymorphisms in primer or probe binding sites can affect test performance. As with any diagnostic test, results should be interpreted in conjunction with clinical findings and other diagnostic procedures.

Test Details

New York Approved