Hexagonal Phospholipid Neutralization
Use
Detection of lupus anticoagulant (phospholipid antibody) presence via qualitative clotting assay. A qualitative assay reported as positive or negative; quantitative clotting time (0–11 seconds reference) assists in diagnosis. Useful in evaluation of antiphospholipid antibodies associated with thrombosis, fetal loss, autoimmune disease (e.g., SLE, rheumatoid arthritis) and transient infections. This test is non‑diagnostic if the patient is on heparin or direct oral anticoagulants. It complements other aPTT‑based assays and supports coagulation evaluation in relevant clinical contexts.
Special Instructions
Not provided.
Limitations
Specimens other than citrated plasma, anticoagulants other than sodium citrate, grossly hemolyzed, lipemic or icteric specimens may be rejected. Test is non‑diagnostic in settings of low‑molecular‑weight heparin, unfractionated heparin, or direct oral anticoagulant use. Plasma heparin > 1.0 IU/ml may give false positives. Not indicated for inpatient evaluation of acute thrombosis.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 3282-1 - aPTT Hex PL PPP
- 3282-1 - aPTT Hex PL PPP
Result Turnaround Time
1-7 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial; light blue‑top (sodium citrate) tube
Collection Instructions
Draw blood in a light blue‑top (sodium citrate) tube; spin down; send 1 mL citrated plasma frozen in a plastic vial.
Causes for Rejection
Specimens other than plasma; anticoagulants other than sodium citrate; hemolysis, lipemia, icterus may cause rejection
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 30 days |