Use

High mobility group (HMG) proteins are nonhistone chromatin factors expressed during embryonic development that function to regulate transcription and cellular differentiation. When expression of HMGA2 is deregulated in cells of adult tissues, this oncofetal protein promotes neoplastic transformation. Abnormal HMGA2 expression has been observed in a wide variety of neoplasms, including uterine leiomyomas, ovarian serous carcinomas, lipomatous tumors, lymphangiomyomatosis, and pancreatic carcinomas. This immunostain may be useful in the differential diagnosis of lower genital tract mesenchymal tumors, showing positivity in the majority of aggressive angiomyxomas.