Histamine, 24-Hour Urine
Use
Histamine is a mediator of the allergic response and its release results in various symptoms such as itching, flushing, hives, vomiting, syncope, and even shock. This test is used to measure the concentration of histamine in a 24-hour urine sample which can help identify elevated levels. High concentrations of histamine may also be associated with certain conditions like gastric carcinoids.
Special Instructions
Patient should avoid direct sunlight and refrain from taking allergy-causing drugs, antihistamines, oral corticosteroids, and substances which block H2 receptors for at least 24 hours prior to specimen collection.
Limitations
This test was performed using a kit that has not been cleared or approved by the FDA. During transport, specimen stability is maintained for 14 days when refrigerated or frozen and up to 48 hours at ambient temperature. Random urine samples are not acceptable and may lead to rejection. The analytical performance characteristics of this test have been determined by Quest Diagnostics Nichols Institute, San Juan Capistrano.
New York Approved
Methodology
Immunoassay (IA)
Biomarkers
LOINC Codes
- 9410-2
- 3167-4
Result Turnaround Time
5-11 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
4 mL
Minimum Volume
2 mL
Container
Plastic, 10-mL tube (T068)
Collection Instructions
Collect urine for 24 hours, with 10 mL 6N HCL preservative. Avoid direct sunlight during the 24-hour collection. Send specimen refrigerated in the plastic, 10-mL urine tube (T068). Collection volume and duration are required.
Patient Preparation
Avoid direct sunlight. Refrain from taking allergy-causing drugs, antihistamines, oral corticosteroids, and substances which block H2 receptors for at least 24 hours prior to collection.
Storage Instructions
Store refrigerated.
Causes for Rejection
Random Urine
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 14 days |
| Frozen | 14 days |