Histamine Plasma
Use
Histamine Plasma test is used to determine the concentration of histamine in the plasma, which can be indicative of allergic reactions, anaphylaxis, or mastocytosis. Histamine, a compound involved in local immune responses, can cause a variety of physiological effects such as inflammation, gastric acid secretion, and smooth muscle contraction. This test aids in diagnosing conditions related to abnormal histamine levels, providing valuable information for treatment plans and allergy assessments.
Special Instructions
The test requires specific handling as the specimen needs to be placed on ice immediately and centrifuged at specific settings. Proper steps must be followed to ensure accurate testing. Submission in a plastic vial is necessary after the plasma is extracted, and the specimen must be sent frozen to the lab.
Limitations
The Histamine Plasma test does not differentiate the source of the elevated histamine levels, be it an allergic, inflammatory, or neoplastic condition. It is not suitable for diagnosing specific allergies or pinpointing the exact cause of the symptoms. Factors such as improper specimen handling, delays in processing, or hemolysis can affect the test results. Gross hemolysis or lipemia and the use of non-EDTA plasma can lead to specimen rejection.
New York Approved
Methodology
Immunoassay (Enzyme Immunoassay (EIA))
Biomarkers
LOINC Codes
- 2416-6
- 2416-6
Result Turnaround Time
4-7 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Immediately place specimen on ice. Centrifuge within 20 minutes of collection at 900 x g for 10 minutes at 4 degrees C. Carefully remove 1 mL of EDTA plasma from the upper part of the tube and place in a plastic vial. Send frozen.
Causes for Rejection
Gross hemolysis, gross lipemia, non-EDTA plasma
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 28 days |