HIV-1 and HIV-2 Antibody Confirmation and Differentiation, Prenatal, Plasma

Casandra

Casandra Test Code MC72374Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID HVDSPCPT Codes 86701, 86702, 87535, 87536, 87538

HIV-1 and HIV-2 Antibody Confirmation and Differentiation, Prenatal, Plasma

Clinical Use

Use

This test is used for confirmation and differentiation of HIV-1 and HIV-2 antibodies in plasma specimens from prenatal patients who show reactive results with 3rd- and 4th-generation HIV serologic assays. It plays a crucial role in determining the presence of HIV-1 and HIV-2 infections, aiding healthcare providers to make accurate diagnoses and treatment plans. However, this test is not intended as a screening test for HIV infection in symptomatic or asymptomatic individuals or as a confirmatory test for blood donor specimens.

Special Instructions

This test is not suitable for follow-up testing of patients with reactive results from any rapid HIV tests, except for pregnant patients who were reactive by the Determine HIV-1/-2 Ag/Ab Combo rapid point-of-care test on serum or plasma. Inappropriate for autopsy or cadaver blood sources. For New York State clients, this test should not be requested for maternal/newborn HIV screening due to state regulatory requirements. Date of collection is required.

Limitations

A negative result for both HIV-1 and HIV-2 antibodies does not rule out acute HIV infection. All positive results should be verified with a second specimen. Participation in HIV-1 vaccine studies may lead to cross-reactivity. Assay performance not established for heat-inactivated specimens, cadaveric specimens, or samples with particulate matter.

Test Details

FDA Approved