HIV-1 and HIV-2 Antibody Confirmation and Differentiation Prenatal, Serum

Casandra

Casandra Test Code MC86164Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID HVPPSCPT Codes 86701, 86702, 87535, 87538

HIV-1 and HIV-2 Antibody Confirmation and Differentiation Prenatal, Serum

Clinical Use

Use

This test is used for confirmation and differentiation of HIV-1 and HIV-2 antibodies in serum specimens from prenatal patients who show reactive results with third-generation and fourth-generation HIV serologic assays. It evaluates antibodies in situations where the initial HIV screening results are reactive, providing further classification of the HIV antibody type present in the sample. This aids in the management and follow-up of HIV-positive patients by distinguishing between HIV-1 and HIV-2 infections, which have different epidemiology and clinical implications.

Special Instructions

This test is not suitable for follow-up testing of patients with reactive results from any rapid HIV tests, except for pregnant patients who were reactive by the Determine HIV-1/-2 Ag/Ab Combo rapid point-of-care test on serum or plasma. The test should not be requested for maternal/newborn HIV screening in New York State due to regulatory requirements.

Limitations

The test is not useful as a screening test for HIV infection in symptomatic or asymptomatic individuals and should not be used for blood donor specimens. Negative antibody results do not rule out acute or early HIV infection, and false positives can occur due to antibodies from non-HIV infections, hypergammaglobulinemic states, or pregnancy. The test cannot be used on heat-inactivated or cadaveric specimens, or ones containing particulate matter.

Test Details

FDA Approved