HIV-1 and HIV-2 Antibody Confirmation and Differentiation Prenatal, Serum
Use
This test is used for confirmation and differentiation of HIV-1 and HIV-2 antibodies in serum specimens from prenatal patients who show reactive results with third-generation and fourth-generation HIV serologic assays. It evaluates antibodies in situations where the initial HIV screening results are reactive, providing further classification of the HIV antibody type present in the sample. This aids in the management and follow-up of HIV-positive patients by distinguishing between HIV-1 and HIV-2 infections, which have different epidemiology and clinical implications.
Special Instructions
Not provided.
Limitations
The test is not useful as a screening test for HIV infection in symptomatic or asymptomatic individuals and should not be used for blood donor specimens. Negative antibody results do not rule out acute or early HIV infection, and false positives can occur due to antibodies from non-HIV infections, hypergammaglobulinemic states, or pregnancy. The test cannot be used on heat-inactivated or cadaveric specimens, or ones containing particulate matter.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Rapid Immunochromatographic Assay)
Biomarkers
HIV-1 Antibody
ProteinHIV-2 Antibody
Protein
LOINC Codes
- 89365-1 - HIV 1 + 2 Ab Pnl SerPlBld IA.rapid
- 68961-2 - HIV1 Ab SerPlBld Ql IA.rapid
- 81641-3 - HIV 2 Ab SerPlBld Ql IA.rapid
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.5 mL
Minimum Volume
0.8 mL
Container
Plastic vial
Collection Instructions
Centrifuge blood collection tube per collection tube manufacturer's instructions and aliquot plasma into plastic vial.
Causes for Rejection
Gross hemolysis is acceptable. Gross lipemia and gross icterus are acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 6 days |
| Frozen | 30 days |