Human Papillomavirus (HPV) High/Low Risk, In Situ Hybridization

Casandra

Casandra Test Code MC85108Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID HPVHLCPT Codes 88364, 88365

Human Papillomavirus (HPV) High/Low Risk, In Situ Hybridization

Clinical Use

Use

The test is used to detect human papillomavirus (HPV) genotypes that are associated with both low-risk and high-risk conditions. Low-risk genotypes such as HPV 6 and 11 are linked to benign hyperplasias like condylomas and papillomas. On the other hand, high-risk genotypes (including but not limited to HPV 16, 18, and others) are linked to cervical, vaginal, vulvar, and head and neck malignancies. These include HPV-related oropharyngeal squamous cell carcinoma (OPSCC), where patients often exhibit better disease-specific survival and overall survival compared to those with HPV-negative OPSCC.

Special Instructions

If additional interpretation or analysis is needed, request a PATHC / Pathology Consultation along with this test. Attach the green pathology address label included in the kit to the outside of the transport container. A pathology/diagnostic report and a brief history are required.

Limitations

Stability of cut paraffin sections may affect staining quality, with best practices suggesting sections be cut within 6 weeks. The results are reported as positive or negative for low-risk types 6 and 11, and high-risk types listed in the test description. This test is not meant for follow-up on previously diagnosed HPV nor should it replace traditional methods of HPV testing.

Test Details

New York Approved

Methodology

Chromosomal / Cytogenetics (ISH)

Biomarkers

Unknown microorganism

Microorganism

HPV types 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82 • Other • Categorical (e.g., Positive / Negative / Indeterminate)