Hyperoxaluria Panel, Random, Urine
Use
This panel aids in distinguishing between primary and secondary hyperoxaluria and further differentiates among primary hyperoxaluria types 1, 2, and 3 by evaluating urinary metabolites: glycolate, glycerate, oxalate, and 4‑hydroxy‑2‑oxoglutarate. Increased urinary oxalate suggests hyperoxaluria; presence of glycolate, glycerate, or HOG points toward primary forms, with type-specific metabolite patterns enabling subclassification. Secondary hyperoxaluria is indicated when oxalate is elevated but other metabolites are normal. Confirmatory molecular testing may follow per diagnostic algorithm.
Special Instructions
Patient age is required. Submission of the Biochemical Genetics Patient Information form (T602) is recommended. If not ordered electronically, include the Biochemical Genetics Test Request (T798) or Renal Diagnostics Test Request (T830) with the specimen. Ordering and interpretative guidance is provided through the Hyperoxaluria Diagnostic Algorithm.
Limitations
Ascorbic acid (vitamin C) can falsely elevate oxalic acid results. All specimens are evaluated for suitability at Mayo Clinic Laboratories. Limitations include potential misclassification if interfering substances are present or if specimen handling deviates from protocol.
New York Approved
Methodology
Mass Spectrometry (GC-MS)
Biomarkers
LOINC Codes
- 53710-0
- 13751-3
- 13749-7
- 13483-3
- 13678-8
- 59462-2
- 18771-6
Result Turnaround Time
3-9 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
10 mL
Minimum Volume
1.1 mL
Container
Plastic, 10‑mL urine tube
Collection Instructions
Collect a random urine specimen; no preservative; immediately freeze specimen.
Causes for Rejection
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 90 days |