Use

This panel aids in distinguishing between primary and secondary hyperoxaluria and further differentiates among primary hyperoxaluria types 1, 2, and 3 by evaluating urinary metabolites: glycolate, glycerate, oxalate, and 4‑hydroxy‑2‑oxoglutarate. Increased urinary oxalate suggests hyperoxaluria; presence of glycolate, glycerate, or HOG points toward primary forms, with type-specific metabolite patterns enabling subclassification. Secondary hyperoxaluria is indicated when oxalate is elevated but other metabolites are normal. Confirmatory molecular testing may follow per diagnostic algorithm.