IgA Subclasses, Serum
Use
This test is useful for investigating immune deficiency due to immunoglobulin A2 deficiency and evaluating patients with anaphylactic transfusion reactions. IgA, the predominant immunoglobulin at mucosal surfaces, consists of 2 subclasses, IgA1 and IgA2, differing in molecular structure and tissue distribution.
Special Instructions
Not provided.
Limitations
Moderate-to-marked lipemia may interfere with testing. Antigen excess, although rare, cannot be excluded, requiring results to be interpreted alongside other laboratory tests and clinical evidence. Results are sensitive to collection and handling conditions of the specimen.
FDA ApprovedNew York Approved
Methodology
Automated Analyzer (Turbidimetry)
Biomarkers
IgA
ProteinIgA1
ProteinIgA2
Protein
LOINC Codes
- 87552-6 - IgA + IgA1 + IgA2 Pnl SerPl
- 2458-8 - IgA SerPl-mCnc
- 6886-6 - IgA1 Ser-mCnc
- 6939-3 - IgA2 Ser-mCnc
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Patient Preparation
Fasting: 12 hours, preferred but not required
Storage Instructions
Refrigerate if not immediately tested; stable for 7 days.
Causes for Rejection
Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 7 days |
| Frozen | 7 days |