IgE Receptor Antibody
Use
Chronic autoimmune urticaria (CIU) may be associated with autoantibodies to the high affinity IgE receptor (Fc-epsilon R1) or to IgE. In the presence of the autoantibodies, cross-linking of the Fc-epsilon-R1 receptor occurs, leading to basophil activation. The laboratory tests for the activation of donor basophils by CIU serum by analyzing the expression of the basophil-specific ectoenzyme, CD203c. A positive result indicates the presence of these autoantibodies or other basophil-activating serum factors, which need to be correlated with clinical findings.
Special Instructions
The test uses a kit/reagent designated by the manufacturer for research use, not for clinical use and an analyte specific reagent (ASR). Results are not intended for use as the sole means for clinical diagnosis or patient management.
Limitations
The performance characteristics of this test have not been cleared or approved by the US Food and Drug Administration. The test is intended for research purposes and should not be used as the sole means for clinical diagnosis. Interpretation must consider the presence of other basophil-activating serum factors besides autoantibodies.
New York Approved
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
Result Turnaround Time
11-14 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.5 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Immediately centrifuge and aliquot 1.5 mL serum into a plastic vial. Send frozen.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 7 days |
| Frozen | 365 days |