Use

The immunoglobulin molecules (antibodies) function as surface receptors for antigens for B lymphocytes and as secretory products of plasma cells forming the humoral arm of the immune system. IgM represents one of the immunoglobulin heavy chain types. IgM positive-B lymphocytes are normally present in the follicular mantle zones and germinal centers. Immunoreactivity is a specific marker for B lymphocytes and plasma cells. Diagnostically, staining for immunoglobulin heavy chains can aid in the diagnosis and classification of small B cell malignant lymphomas and multiple myeloma.