Immunoglobulin D (IgD), Serum
Use
This test is useful for providing information on the humoral immune status and identifying an IgD monoclonal gammopathy. Immunoglobulins are formed by plasma cells as part of the humoral immune response. Increased Ig concentrations occur due to immunoglobulin proliferation from various conditions like hepatic diseases, infections, autoimmune diseases, as well as in conditions such as multiple myeloma. Changes in IgD concentration can indicate changes in monoclonal IgD plasma cell clone size.
Special Instructions
Fasting for 8 hours is preferred but not required before specimen collection. For differentiating between polyclonal and monoclonal IgD, the test 'IFXED / Immunofixation Heavy Chain Type Delta and Epsilon, Serum' must be ordered separately. Moderate to marked lipemia may interfere with test results.
Limitations
An elevated IgD level cannot solely indicate a monoclonal IgD protein due to potential antigen excess and polyclonal responses. Results should be considered in conjunction with other tests like serum protein electrophoresis, and interpreted alongside clinical evidence. The presence of IgD monoclonal protein is generally suggestive of a malignant plasma cell disorder.
FDA ApprovedNew York Approved
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 2460-4
- 2460-4
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Serum gel preferred, Red top acceptable
Collection Instructions
Centrifuge and aliquot serum into a plastic vial. Use Sarstedt 5 mL Aliquot Tube (T914).
Patient Preparation
Fasting: 8 hours, preferred but not required
Causes for Rejection
Gross lipemia, Heat-activated specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 21 days |
| Refrigerated | 28 days |
| Frozen | 28 days |