Immunoglobulin E (IgE), Serum
Use
This test is useful for evaluating patients with suspected conditions associated with elevated levels of total IgE such as allergic diseases, primary immunodeficiencies, infections, malignancies, or other inflammatory diseases. It plays a role in the diagnostic evaluation of allergic bronchopulmonary aspergillosis and helps identify candidates for anti-IgE therapy, such as omalizumab treatment.
Special Instructions
For a listing of allergens available for testing, see the Allergens - Immunoglobulin E (IgE) Antibodies resource. It's important to properly prepare and handle specimens to avoid diagnostic confusion. Ensure the serum is centrifuged and aliquoted into a plastic vial for submission.
Limitations
Certain limitations exist with the diagnostic use of total IgE measurement. An elevated concentration is not exclusively diagnostic for allergic disease and must be interpreted in the clinical context of the patient. A normal IgE concentration does not rule out allergic disease, as it can present in normal ranges in some patients, especially with limited allergen exposure.
FDA ApprovedNew York Approved
Methodology
Immunoassay (FEIA)
Biomarkers
LOINC Codes
- 19113-0
- 19113-0
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
Not provided
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis and gross lipemia are acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 90 days |