Use

This test is particularly useful for diagnosing multiple sclerosis and other demyelinating conditions. It helps evaluate patients who present with a clinically isolated syndrome that mimics multiple sclerosis symptoms like headaches, optic neuritis, and fatigue. The test is recommended when imaging findings are atypical or in demographics where multiple sclerosis is less common, such as children, elderly, or non-White populations. This test is not useful if a clear diagnosis is already established, as a positive result does not correlate with disease severity or outcomes.