Immunoglobulins, CSF Quantitative
Use
This test is used to quantitatively measure the levels of immunoglobulins in cerebrospinal fluid (CSF). Quantification of immunoglobulins in CSF is useful for diagnosing and monitoring neurological diseases, such as multiple sclerosis, where an abnormal immune response involves the central nervous system. Elevated immunoglobulin levels in CSF can indicate a breach of the blood-brain barrier or intrathecal synthesis of immunoglobulins, which are often associated with inflammatory conditions.
Special Instructions
Specimens must be collected in a leak-proof container and transferred to a sterile vial. It is recommended to centrifuge spinal fluid to remove cellular material before transferring 1 mL into a plastic vial. Prompt refrigeration is required after collection to maintain specimen integrity.
Limitations
This test does not distinguish between intrathecally synthesized immunoglobulins and those derived from a compromised blood-brain barrier. False results can occur if the specimen is hemolyzed or grossly bloody. Interpretation of results should be done with consideration of the patient's clinical context and other diagnostic tests.
New York Approved
Methodology
Immunoassay (Quantitative Immunoturbidimetry)
Biomarkers
LOINC Codes
- 2471-1
- 2464-6
- 2457-0
Result Turnaround Time
1-13 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
1 mL
Minimum Volume
0.6 mL
Container
Sterile vial
Collection Instructions
Centrifuge spinal fluid to remove cellular material. Transfer 1 mL into a plastic vial. Send refrigerated.
Causes for Rejection
Hemolysis: Reject; Thawing: Cold OK; Warm reject; Grossly bloody: Reject
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 30 days |
| Frozen | 180 days |