Insulin-Like Growth Factor-1, Mass Spectrometry, Serum
Use
The test is used for evaluating growth disorders, growth hormone deficiency or excess in children and adults, monitoring recombinant human growth hormone treatment, and following up individuals with acromegaly and gigantism. Serum levels of IGF1 provide a stable and integrated measurement of growth hormone production and tissue effect, and can indicate growth hormone deficiency, resistance, or excess.
Special Instructions
Not provided.
Limitations
Tests exhibit significant variability among platforms; direct comparison of results obtained by different assays is challenging. IGF1 or IGFBP3 can't be reliably used as prognostic markers in cancers like breast, colon or prostate. Variants in IGF1 may lead to overestimation of active IGF1; MS-based assays can differentiate active forms better than immunoassays. Serum IGF1 values are age-dependent and must be interpreted considering patient age.
New York Approved
Methodology
Mass Spectrometry (LC-MS)
Biomarkers
LOINC Codes
- 2484-4 - IGF-I SerPl-mCnc
- 2484-4 - IGF-I SerPl-mCnc
- 73561-3 - IGF-I Z-score SerPl
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 72 hours |
| Frozen | 28 days |