Isocyanate HDI, IgE, Serum
Use
The test is useful for establishing a diagnosis of an allergy to isocyanate HDI, identifying the allergen responsible for eliciting signs and symptoms, and confirming sensitization prior to beginning immunotherapy. It is not useful for patients previously treated with immunotherapy or when medical management does not depend on allergen specificity identification.
Special Instructions
For multiple allergens requested, the specimen volume must be calculated accordingly (0.5 mL per 5 allergens). If not ordering electronically, complete and send an Allergen Test Request (T236) with the specimen.
Limitations
Testing for IgE antibodies is not recommended in patients previously treated with immunotherapy where residual clinical sensitivity needs to be assessed, as well as in cases where identification of allergen specificity is not critical for patient management. The presence of clinically insignificant sensitivity can result in measurable IgE levels, and false positives can occur with very high serum IgE due to nonspecific binding.
New York Approved
Methodology
Immunoassay (FEIA)
Biomarkers
LOINC Codes
- 7429-4
- 7429-4
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
0.3 mL for 1 allergen; (0.05 mL x number of allergens) + 0.25 mL deadspace for more than 1 allergen
Container
Preferred: Serum gel; Acceptable: Red top; Submission: Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Storage Instructions
Transport refrigerated, preferred. Can also be frozen up to 90 days.
Causes for Rejection
Gross hemolysis: OK; Gross lipemia: OK.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 90 days |