JC Virus Detection by In Situ Hybridization
Use
The JC virus is the causal agent of progressive multifocal leukoencephalopathy (PML), a severe disease that affects the central nervous system and occurs in individuals with compromised immune systems. This test is useful for confirming the clinical and histopathologic diagnosis of PML, a rare but serious condition associated with various immune deficiencies such as lymphoproliferative disorders, sarcoidosis, tuberculosis, and AIDS.
Special Instructions
Not provided.
Limitations
There is potential cross-reactivity between polyoma (BK) and JC virus in situ hybridization (ISH) testing. The age of a cut paraffin section can affect staining quality. Stability thresholds can vary, and it is best practice to cut paraffin sections within 6 weeks for optimal results.
New York Approved
Methodology
Chromosomal / Cytogenetics (ISH)
Biomarkers
JC Virus
Microorganism
LOINC Codes
- 50595-8 - Path Interp Spec-Imp
- 19139-5 - Pathologist name
- 81178-6 - Block description and site Spec
- 62364-5 - Test performance info Spec
- 80398-1 - Unique ID Current sample
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Entire block
Minimum Volume
Not provided
Container
Pathology Packaging Kit (T554)
Collection Instructions
Special
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |
| Refrigerated | Refrigerated |