Leptin
Use
Leptin is a hormone predominantly made by adipose cells and enterocytes in the small intestine that helps to regulate energy balance by inhibiting hunger. It acts on cell receptors in the arcuate and ventromedial nuclei, as well as other parts of the hypothalamus and in the pituitary. Leptin counteracts the effects of neuropeptide Y, a potent feeding stimulant secreted by cells in the gut and in the hypothalamus, and anandamide, another potent feeding stimulant that binds to the same receptors as THC, the primary active compound in cannabis. It also promotes the synthesis of alpha-MSH, an appetite suppressant, from its precursor proopiomelanocortin.
Special Instructions
Fasting is recommended prior to specimen collection. Utilize a Red top or Serum gel tube for collection. Handle specimen with care to avoid hemolysis or lipemia, which can cause rejection.
Limitations
The Leptin test is not FDA approved and was developed by LabCorp, with performance characteristics determined by LabCorp itself. The test may not be as accurate for individuals with extreme BMI values, and minimum specimen volume requirements do not allow for repeat analyses if needed. Hemolysis and lipemia can cause sample rejection, and improper specimen storage may affect stability.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 21365-2
- 21365-2
Result Turnaround Time
8-14 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red top or Serum gel
Collection Instructions
Centrifuge within 45 minutes of collection and aliquot serum into a plastic vial. Send frozen.
Patient Preparation
Fasting: Recommended
Causes for Rejection
Hemolysis, Lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 days |
| Refrigerated | 14 days |