Leptospira, IgM, Serum
Use
This test aids in the diagnosis of leptospirosis, a zoonotic disease prevalent worldwide, especially in tropical climates. It detects IgM-class antibodies against Leptospira species, which are gram-negative spirochetes. The test is particularly useful for diagnosing acute or recent leptospirosis due to infection with Leptospira species. While a positive test suggests recent infection, it must be considered alongside the patient's clinical presentation and exposure history due to possible persistent antibodies from past infections.
Special Instructions
If ordering non-electronically, the Infectious Disease Serology Test Request form must accompany the specimen. Patients should consider submitting acute and convalescent specimens collected 2 or more weeks apart to check for seroconversion.
Limitations
This test is not suitable for establishing cure or therapy response, and it cannot differentiate between acute or past infections. Temporal variation in IgM immune response means a single negative result should not rule out leptospirosis. Clinical correlation is essential, and a negative result may require follow-up testing with a convalescent sample collected 2 to 3 weeks later.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 23201-7
- 23201-7
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.3 mL
Minimum Volume
0.1 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into plastic vial.
Causes for Rejection
Gross hemolysis; Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 30 days |
| Frozen | 30 days |