Leukemia/Lymphoma Immunophenotyping, Flow Cytometry, Varies
Use
This test is useful for evaluating lymphocytoses of undetermined etiology and identifying B- and T-cell lymphoproliferative disorders involving blood and bone marrow. It aids in distinguishing acute lymphoblastic leukemia (ALL) from acute myeloid leukemia (AML) and in the immunologic subtyping of acute leukemias. This test is also important for distinguishing reactive lymphocytes and lymphoid hyperplasia from malignant lymphoma and between malignant lymphoma and acute leukemia. It is used for phenotypic subclassification of B- and T-cell chronic lymphoproliferative disorders, including chronic lymphocytic leukemia, mantle cell lymphoma, and hairy cell leukemia. Additionally, it recognizes AML with minimal morphologic or cytochemical evidence of differentiation and recognizes monoclonal plasma cells.
Special Instructions
Not provided.
Limitations
This test is not intended for detection of minimal residual disease below 5% blasts and is not appropriate for diagnosis of sarcoidosis, hypersensitivity pneumonitis, interstitial lung diseases, or differentiating between pulmonary tuberculosis and sarcoidosis. It cannot support diagnosis of these conditions, and specimens sent for such purposes will be rejected.
New York Approved
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 101119-6 - Leuk and lymphma immnphntypng Spec
- 22635-7 - Path report.microscopic Spec Other Stn
- 30954-2 - Relevant dx tests/lab data note
- 34574-4 - Path report.final Dx Spec
- 42349-1
- 31208-2 - Specimen source
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
6 mL
Minimum Volume
3 mL
Container
Yellow top (ACD solution A or B)
Collection Instructions
Send whole blood specimen in original tube. Do not aliquot. Label specimen as blood. If possible, include 5 to 10 unstained blood smears, which must be labeled with two unique identifiers.
Causes for Rejection
Gross hemolysis, Fully clotted whole blood
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 4 days |