Use

This test is useful for evaluating lymphocytoses of undetermined etiology and identifying B- and T-cell lymphoproliferative disorders involving blood and bone marrow. It aids in distinguishing acute lymphoblastic leukemia (ALL) from acute myeloid leukemia (AML) and in the immunologic subtyping of acute leukemias. This test is also important for distinguishing reactive lymphocytes and lymphoid hyperplasia from malignant lymphoma and between malignant lymphoma and acute leukemia. It is used for phenotypic subclassification of B- and T-cell chronic lymphoproliferative disorders, including chronic lymphocytic leukemia, mantle cell lymphoma, and hairy cell leukemia. Additionally, it recognizes AML with minimal morphologic or cytochemical evidence of differentiation and recognizes monoclonal plasma cells.