Luteinizing Hormone (LH) Beta Immunostain, Technical Component Only
Use
The immunohistochemical detection of luteinizing hormone (LH) beta subunit is useful in the classification of pituitary adenomas. Its expression is usually associated with gonadotroph adenomas, which are typically non-functional pituitary tumors. The clinical significance lies in aiding the differential diagnosis of pituitary adenomas and providing insights into potential hormone production and secretion characteristics of the tumor.
Special Instructions
Not provided.
Limitations
This test does not include a pathologist interpretation, so results must be interpreted in conjunction with the patient's clinical history and other diagnostic tests by a qualified pathologist. Immunoreactivity of the tissue may be affected by the age of the paraffin section and environmental factors affecting the charge of glass slides, which can in turn impact staining quality due to poor slide surface chemistry. Stability thresholds can vary widely depending on antigen characteristics and should be confirmed based on current literature and best practices.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Luteinizing Hormone (LH) Beta
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Preferred specimens include formalin-fixed, paraffin-embedded tissue blocks or two unstained, positively charged glass slides measuring 25- x 75- x 1-mm with sections cut at 4 microns. Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |
| Refrigerated | Refrigerated |