Lyme Central Nervous System Infection IgG with Antibody Index Reflex, Serum and Spinal Fluid
Use
This test aids in the diagnosis of neuroinvasive Lyme disease or neuroborreliosis caused by Borrelia species, such as Borrelia burgdorferi, Borrelia garinii, and Borrelia afzelli. It assesses IgG antibody levels to Borrelia species in spinal fluid and serum, differentiating between intrathecal antibody synthesis indicative of neuroinvasive Lyme disease and antibody presence from passive diffusion or blood contamination of CSF.
Special Instructions
Not provided.
Limitations
A negative result does not rule out neuroinvasive Lyme disease, especially in patients with early infection where antibodies may not yet be present. False positives can occur in patients with syphilis or Leptospira infections. Testing of serum should also follow the CDC's standard 2-tiered testing algorithm.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
IgG
Antibody
LOINC Codes
- 92815-0 - Borrelia af+burg+gari IgG Pnl Ser+CSF
- 92813-5 - B afz+burg+gari IgG CSF Ql IA
- 69048-7 - Immunologist review
- 92814-3 - B afz+burg+gari IgG Ser Ql IA
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
1.2 mL
Minimum Volume
Not provided
Container
Sterile vial
Collection Instructions
Collect 1.2 mL of CSF, using the second, third, or fourth vial from the lumbar puncture. Avoid the first vial.
Causes for Rejection
Reject if contaminated with blood.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 11 days |
| Frozen | 35 days |