Lymphocyte Proliferation to Mitogens, Blood

Casandra

Casandra Test Code MC85296Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID LPMGFCPT Code 86353

Lymphocyte Proliferation to Mitogens, Blood

Clinical Use

Use

This test is useful for assessing T-cell function in patients undergoing immunosuppressive therapy, including those with solid-organ transplants. It helps evaluate patients suspected of having impaired cellular immunity, including those with primary immunodeficiencies such as DiGeorge syndrome and severe combined immunodeficiency, as well as secondary immunodeficiencies. The test is also valuable in assessing the recovery of T-cell function following bone marrow or hematopoietic stem cell transplantation.

Special Instructions

For serial monitoring, it is recommended to perform specimen collection at the same time of day. If specimens are not received in the laboratory by Friday at 4 pm (CST), the test may be canceled. Specimens arriving on weekends and observed holidays may also be canceled. Ensure to ship the specimen using an Ambient Shipping Box-Critical Specimens Only (T668).

Limitations

Interpretation of results may be affected by factors such as patient use of steroids or immunosuppressive agents. Specimens older than 24 hours or containing gross hemolysis or lipemia might yield unreliable results. Timing and consistency in blood collection are crucial for accurate monitoring. The test does not provide absolute correlation between in vitro T-cell proliferation and clinical immunodeficiency.

Test Details

New York Approved